Detecting high-risk (HR) genotypes associated with the development of cervical cancer Aiding in triaging women with abnormal Pap smear test results Individual genotyping of human papillomavirus (HPV)-16 and/or HPV-18 if present Results of HPV-16 and HPV-18 genotyping can aid in triaging women with positive HR-HPV but negative Pap smear results This testing is intended for use in clinical A negative HPV test result means that the test found no high risk HPV types. A positive result means that the test found high risk types of HPV in the cervix, and people may 1. HPV Co-Testing (recommended in women 30-65yrs.) If Pap is negative reflex to HPV high risk and if positive then HPV Genotyping 16/18. 2. Reflex HPV High Risk (ASCUS or LSIL Pap results) 3. Reflex HPV High Risk in younger women (21-29 yrs.) with prior abnormal Pap/biopsy results. 4. No HPV DNA Reflex. There are four possible results from the cervical screening process, all of which require different action to be taken. These are: Low risk (HPV not detected): This means that no high-risk (cancer causing) HPV was found on your cervix. The chance of developing cervical cell changes that would need treatment in the next five years are very low. Women with negative results (including women who were positive for low-risk HPV types) were categorized as test negative. Since women with inadequate Pap results are usually asked to return for a repeat test, Pap and HPV DNA test results that were inadequate, missing, or insufficient were initially coded as positive. . Background We evaluated the prognostic and diagnostic ability of p16/Ki-67 immunocytochemistry, HPV E6/E7 mRNA testing and HPV DNA assay in triaging ASCUS to find a way to manage cervical lesions more effectively. Methods We conducted a prospective study through follow-up. The detection methods of the three factors: p16/Ki-67 immunocytochemistry conducted by using the CINtec® Plus Kit, E6/E7 Briefly, women aged 30–64 years were screened with cytology and HPV testing and those with negative results for both tests exited the study, while those with abnormal cytology ASC-US or worse (ASC-US+) and/or with positive high-risk HPV test were referred to colposcopy with biopsy of observed lesions and histological assessment. HPV screening or HPV/cytology co-testing every 5 years for women age d 30-65 years old [2]. However, decreases in HR HPV positivity rates due to HPV vaccination and additional research have The test will show if it found types of HPV that could cause cancer. The results may be: Negative. This means that the test didn't find HPV types that could cause cancer. Or this means it found only types that carry a low risk for cancer. Positive. This means the test found at least 1 HPV type that could cause cancer. A total of 12,706 person-times had at least 1 positive test for any HPV DNA over the 5 years. Among these, 632 subjects with 1,020 person-time data were involved in this analysis . All HPV-negative subjects (N = 23,196) assembled in the first half of 2017 were adopted

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